Control of neurite growth and guidance by an inhibitory cell-body signal.

ABSTRACT: The development of a functional nervous system requires tight control of neurite growth and guidance by extracellular chemical cues. Neurite growth is astonishingly sensitive to shallow concentration gradients, but a widely observed feature of both growth and guidance regulation, with important consequences for development and regeneration, is that both are only elicited over the same relatively narrow range of concentrations. Here we show that all these phenomena can be explained within one theoretical framework. We first test long-standing explanations for the suppression of the trophic effects of nerve growth factor at high concentrations, and find they are contradicted by experiment. Instead we propose a new hypothesis involving inhibitory signalling among the cell bodies, and then ext

SUBMITTER: Bicknell BA 

PROVIDER: S-EPMC6013027 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature