Ontology highlight
ABSTRACT:
SUBMITTER: Bicknell BA
PROVIDER: S-EPMC6013027 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Bicknell Brendan A BA Pujic Zac Z Dayan Peter P Goodhill Geoffrey J GJ
PLoS computational biology 20180621 6
The development of a functional nervous system requires tight control of neurite growth and guidance by extracellular chemical cues. Neurite growth is astonishingly sensitive to shallow concentration gradients, but a widely observed feature of both growth and guidance regulation, with important consequences for development and regeneration, is that both are only elicited over the same relatively narrow range of concentrations. Here we show that all these phenomena can be explained within one the ...[more]