Ontology highlight
ABSTRACT:
SUBMITTER: Ross RA
PROVIDER: S-EPMC6013253 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Ross Rachel A RA Leon Silvia S Madara Joseph C JC Schafer Danielle D Fergani Chrysanthi C Maguire Caroline A CA Verstegen Anne Mj AM Brengle Emily E Kong Dong D Herbison Allan E AE Kaiser Ursula B UB Lowell Bradford B BB Navarro Victor M VM
eLife 20180615
Pituitary adenylate cyclase activating polypeptide (PACAP, <i>Adcyap1</i>) is a neuromodulator implicated in anxiety, metabolism and reproductive behavior. PACAP global knockout mice have decreased fertility and PACAP modulates LH release. However, its source and role at the hypothalamic level remain unknown. We demonstrate that PACAP-expressing neurons of the ventral premamillary nucleus of the hypothalamus (PMV<sup>PACAP</sup>) project to, and make direct contact with, kisspeptin neurons in th ...[more]