Ontology highlight
ABSTRACT:
SUBMITTER: Tuyishime S
PROVIDER: S-EPMC6013748 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
EBioMedicine 20180304
We report on prime-boost vaccine regimens with two simian adenovirus (Ad) vectors (SAdV) or two human serotype Ad vectors (HAdV) expressing Gag and gp160 of simian immunodeficiency virus (SIV)<sub>mac239</sub> tested in HAdV-seropositive rhesus macaques (RMs) repeatedly challenged rectally with low doses of SIV<sub>mac251.</sub> Both vaccine regimens reduced set point and peak viral loads (PVL) and accelerated viral clearance. In SAdV-vaccinated controller genotype RMs resistance against infecti ...[more]