Ontology highlight
ABSTRACT:
SUBMITTER: Panja S
PROVIDER: S-EPMC6013754 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
EBioMedicine 20180412
Therapeutic resistance is a central problem in clinical oncology. We have developed a systematic genome-wide computational methodology to allow prioritization of patients with favorable and poor therapeutic response. Our method, which integrates DNA methylation and mRNA expression data, uncovered a panel of 5 differentially methylated sites, which explain expression changes in their site-harboring genes, and demonstrated their ability to predict primary resistance to androgen-deprivation therapy ...[more]