Ontology highlight
ABSTRACT: Background
Tigecycline is an 'immature' antibiotic for children. We report the youngest surviving patient who received a complete tigecycline treatment, and no significant adverse effects occurred in the patient.Case presentation
The 3-month old infant suffered from a catheter-associated bloodstream infection by multiple drug resistant Klebsiella pneumoniae. Tigecycline was considered as a salvage therapy to control the severe sepsis. The therapy consisted of 3 mg/kg as a loading dose and 1.5 mg/kg Q12 h as a maintenance dose for 26 days.Conclusion
Current researches are limited in clinical trials directly focused on children. This therapeutic schedule might be safe for patients who are above 3 months old.
SUBMITTER: Peng C
PROVIDER: S-EPMC6014034 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Peng Cheng C Wang Xiaofeng X Zhang Jiangwei J Jiang Yi Y Hou Xinlin X
Gut pathogens 20180622
<h4>Background</h4>Tigecycline is an 'immature' antibiotic for children. We report the youngest surviving patient who received a complete tigecycline treatment, and no significant adverse effects occurred in the patient.<h4>Case presentation</h4>The 3-month old infant suffered from a catheter-associated bloodstream infection by multiple drug resistant <i>Klebsiella pneumoniae</i>. Tigecycline was considered as a salvage therapy to control the severe sepsis. The therapy consisted of 3 mg/kg as a ...[more]