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Tigecycline application in a 3-month-old infant with multiple drug resistant Klebsiella pneumonia: a case report.


ABSTRACT:

Background

Tigecycline is an 'immature' antibiotic for children. We report the youngest surviving patient who received a complete tigecycline treatment, and no significant adverse effects occurred in the patient.

Case presentation

The 3-month old infant suffered from a catheter-associated bloodstream infection by multiple drug resistant Klebsiella pneumoniae. Tigecycline was considered as a salvage therapy to control the severe sepsis. The therapy consisted of 3 mg/kg as a loading dose and 1.5 mg/kg Q12 h as a maintenance dose for 26 days.

Conclusion

Current researches are limited in clinical trials directly focused on children. This therapeutic schedule might be safe for patients who are above 3 months old.

SUBMITTER: Peng C 

PROVIDER: S-EPMC6014034 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Tigecycline application in a 3-month-old infant with multiple drug resistant <i>Klebsiella pneumonia</i>: a case report.

Peng Cheng C   Wang Xiaofeng X   Zhang Jiangwei J   Jiang Yi Y   Hou Xinlin X  

Gut pathogens 20180622


<h4>Background</h4>Tigecycline is an 'immature' antibiotic for children. We report the youngest surviving patient who received a complete tigecycline treatment, and no significant adverse effects occurred in the patient.<h4>Case presentation</h4>The 3-month old infant suffered from a catheter-associated bloodstream infection by multiple drug resistant <i>Klebsiella pneumoniae</i>. Tigecycline was considered as a salvage therapy to control the severe sepsis. The therapy consisted of 3 mg/kg as a  ...[more]

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