A genetic variant in IL-15R? correlates with physical activity among European-American adults.
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ABSTRACT:
SUBMITTER: Bruneau M
PROVIDER: S-EPMC6014439 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
A genetic variant in IL-15Rα correlates with physical activity among European-American adults.
Bruneau Michael M Walsh Sean S Selinsky Eric E Ash Garrett G Angelopoulos Theodore J TJ Clarkson Priscilla P Gordon Paul P Moyna Niall N Visich Paul P Zoeller Robert R Thompson Paul P Gordish-Dressman Heather H Hoffman Eric E Devaney Joseph J Pescatello Linda S LS
Molecular genetics & genomic medicine 20180406 3
<h4>Background</h4>Interleukin-15 (IL-15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha-receptor (IL-15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among European-American adults.<h4>Methods</h4>Men (n = 240, 23.7 ± 0.3 year, body mass index [BMI] 25.3 ± 0.3 kg/m<sup>2</sup> ) and women (n = 292, ...[more]
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