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Investigation of serotonergic Parkinson's disease-related covariance pattern using [11C]-DASB/PET.


ABSTRACT: We used positron emission tomography imaging with [11C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)- benzonitrile (DASB) and principal component analysis to investigate whether a specific Parkinson's disease (PD)-related spatial covariance pattern could be identified for the serotonergic system. We also explored if non-manifesting leucine-rich repeat kinase 2 (LRRK2) mutation carriers, with normal striatal dopaminergic innervation as measured with [11C]-dihydrotetrabenazine (DTBZ), exhibit a distinct spatial covariance pattern compared to healthy controls and subjects with manifest PD. 15 subjects with sporadic PD, eight subjects with LRRK2 mutation-associated PD, nine LRRK2 non-manifesting mutation carriers, and nine healthy controls participated in the study. The analysis was applied to the DASB non-displaceable binding potential values evaluated in 42 pre-defined regions of interest. PD was found to be associated with a specific spatial covariance pattern, comprising relatively decreased DASB binding in the caudate, putamen and substantia nigra and relatively preserved binding in the hypothalamus and hippocampus; the expression of this pattern in PD subjects was significantly higher than in healthy controls (P?P?P?P?

SUBMITTER: Fu JF 

PROVIDER: S-EPMC6014591 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Investigation of serotonergic Parkinson's disease-related covariance pattern using [<sup>11</sup>C]-DASB/PET.

Fu Jessie Fanglu JF   Klyuzhin Ivan I   Liu Shuying S   Shahinfard Elham E   Vafai Nasim N   McKenzie Jessamyn J   Neilson Nicole N   Mabrouk Rostom R   Sacheli Matthew A MA   Wile Daryl D   McKeown Martin J MJ   Stoessl A Jon AJ   Sossi Vesna V  

NeuroImage. Clinical 20180521


We used positron emission tomography imaging with [<sup>11</sup>C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)- benzonitrile (DASB) and principal component analysis to investigate whether a specific Parkinson's disease (PD)-related spatial covariance pattern could be identified for the serotonergic system. We also explored if non-manifesting leucine-rich repeat kinase 2 (LRRK2) mutation carriers, with normal striatal dopaminergic innervation as measured with [<sup>11</sup>C]-dihydrotetrabena  ...[more]

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