Ontology highlight
ABSTRACT:
SUBMITTER: Sun T
PROVIDER: S-EPMC6014607 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Sun Tingting T Aceto Nicola N Meerbrey Kristen L KL Kessler Jessica D JD Zhou Chunshui C Migliaccio Ilenia I Nguyen Don X DX Pavlova Natalya N NN Botero Maria M Huang Jian J Bernardi Ronald J RJ Schmitt Earlene E Hu Guang G Li Mamie Z MZ Dephoure Noah N Gygi Steven P SP Rao Mitchell M Creighton Chad J CJ Hilsenbeck Susan G SG Shaw Chad A CA Muzny Donna D Gibbs Richard A RA Wheeler David A DA Osborne C Kent CK Schiff Rachel R Bentires-Alj Mohamed M Elledge Stephen J SJ Westbrook Thomas F TF
Cell 20110301 5
Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood and is refractory to current targeted therapies. Using a genetic screen, we identify the PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12 potently suppresses mammary epithelial cell proliferation and transformation. PTPN12 is frequently compromised in human TNBCs, and we identify an upstream tumor-suppressor network that posttranscriptionally controls PTPN12. PTPN12 suppresses transformation ...[more]