Ontology highlight
ABSTRACT:
SUBMITTER: Dole NS
PROVIDER: S-EPMC6014615 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Dole Neha S NS Mazur Courtney M CM Acevedo Claire C Lopez Justin P JP Monteiro David A DA Fowler Tristan W TW Gludovatz Bernd B Walsh Flynn F Regan Jenna N JN Messina Sara S Evans Daniel S DS Lang Thomas F TF Zhang Bin B Ritchie Robert O RO Mohammad Khalid S KS Alliston Tamara T
Cell reports 20171101 9
Poor bone quality contributes to bone fragility in diabetes, aging, and osteogenesis imperfecta. However, the mechanisms controlling bone quality are not well understood, contributing to the current lack of strategies to diagnose or treat bone quality deficits. Transforming growth factor beta (TGF-β) signaling is a crucial mechanism known to regulate the material quality of bone, but its cellular target in this regulation is unknown. Studies showing that osteocytes directly remodel their perilac ...[more]