Ontology highlight
ABSTRACT:
SUBMITTER: Aiello NM
PROVIDER: S-EPMC6014628 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Aiello Nicole M NM Maddipati Ravikanth R Norgard Robert J RJ Balli David D Li Jinyang J Yuan Salina S Yamazoe Taiji T Black Taylor T Sahmoud Amine A Furth Emma E EE Bar-Sagi Dafna D Stanger Ben Z BZ
Developmental cell 20180601 6
Epithelial-mesenchymal transition (EMT) is strongly implicated in tumor cell invasion and metastasis. EMT is thought to be regulated primarily at the transcriptional level through the repressive activity of EMT transcription factors. However, these classical mechanisms have been parsed out almost exclusively in vitro, leaving questions about the programs driving EMT in physiological contexts. Here, using a lineage-labeled mouse model of pancreatic ductal adenocarcinoma to study EMT in vivo, we f ...[more]