Dataset Information

Testosterone treatment and the risk of aggressive prostate cancer in men with low testosterone levels.

ABSTRACT:

Purpose

Testosterone treatment of men with low testosterone is common and, although relatively short-term, has raised concern regarding an increased risk of prostate cancer (CaP). We investigated the association between modest-duration testosterone treatment and incident aggressive CaP.

Materials and methods

Retrospective inception cohort study of male Veterans aged 40 to 89 years with a laboratory-defined low testosterone measurement from 2002 to 2011 and recent prostate specific antigen (PSA) testing; excluding those with recent testosterone treatment, prostate or breast cancer, high PSA or prior prostate biopsy. Histologically-confirmed incident aggressive prostate cancer or any prostate cancer were the primary and secondary outcomes, respectively.

Results

Of the 147,593 men included, 58,617 were treated with testosterone. 313 aggressive CaPs were diagnosed, 190 among untreated men (incidence rate (IR) 0.57 per 1000 person years, 95% CI 0.49-0.65) and 123 among treated men (IR 0.58 per 1000 person years; 95% CI 0.48-0.69). After adjusting for age, race, hospitalization during year prior to cohort entry, geography, BMI, medical comorbidities, repeated testosterone and PSA testing, testosterone treatment was not associated with incident aggressive CaP (HR 0.89; 95% CI 0.70-1.13) or any CaP (HR 0.90; 95% CI 0.81-1.01). No association between cumulative testosterone dose or formulation and CaP was observed.

Conclusions

Among men with low testosterone levels and normal PSA, testosterone treatment was not associated with an increased risk of aggressive or any CaP. The clinical risks and benefits of testosterone treatment can only be fully addressed by large, longer-term randomized controlled trials.

SUBMITTER: Walsh TJ

PROVIDER: S-EPMC6014638 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Testosterone treatment and the risk of aggressive prostate cancer in men with low testosterone levels.

Walsh Thomas J TJ Shores Molly M MM Krakauer Chloe A CA Forsberg Christopher W CW Fox Alexandra E AE Moore Kathryn P KP Korpak Anna A Heckbert Susan R SR Zeliadt Steven B SB Kinsey Chloe E CE Thompson Mary Lou ML Smith Nicholas L NL Matsumoto Alvin M AM

PloS one 20180622 6

<h4>Purpose</h4>Testosterone treatment of men with low testosterone is common and, although relatively short-term, has raised concern regarding an increased risk of prostate cancer (CaP). We investigated the association between modest-duration testosterone treatment and incident aggressive CaP.<h4>Materials and methods</h4>Retrospective inception cohort study of male Veterans aged 40 to 89 years with a laboratory-defined low testosterone measurement from 2002 to 2011 and recent prostate specific ...[more]

PMID: 29933385

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Dataset Information

Testosterone treatment and the risk of aggressive prostate cancer in men with low testosterone levels.

Purpose

Materials and methods

Results

Conclusions

Publications

Testosterone treatment and the risk of aggressive prostate cancer in men with low testosterone levels.

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