Ontology highlight
ABSTRACT:
SUBMITTER: Murakami T
PROVIDER: S-EPMC6015004 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Murakami Tomoyuki T Kim Jiwon J Li Yi Y Green Glenn Edward GE Shikanov Ariella A Ono Akira A
Nature communications 20180622 1
Fibroblastic reticular cells (FRCs) are stromal cells in secondary lymphoid organs, the major sites for HIV-1 infection of CD4<sup>+</sup> T cells. Although FRCs regulate T cell survival, proliferation, and migration, whether they play any role in HIV-1 spread has not been studied. Here, we show that FRCs enhance HIV-1 spread via trans-infection in which FRCs capture HIV-1 and facilitate infection of T cells that come into contact with FRCs. FRCs mediate trans-infection in both two- and three-di ...[more]