Shared Genetic Contribution of Type 2 Diabetes and Cardiovascular Disease: Implications for Prognosis and Treatment.
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ABSTRACT:
SUBMITTER: Strawbridge RJ
PROVIDER: S-EPMC6015804 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Shared Genetic Contribution of Type 2 Diabetes and Cardiovascular Disease: Implications for Prognosis and Treatment.
Strawbridge Rona J RJ van Zuydam Natalie R NR
Current diabetes reports 20180625 8
<h4>Purpose of review</h4>The increased cardiovascular disease (CVD) risk in subjects with type 2 diabetes (T2D) is well established. This review collates the available evidence and assesses the shared genetic background between T2D and CVD: the causal contribution of common risk factors to T2D and CVD and how genetics can be used to improve drug development and clinical outcomes.<h4>Recent findings</h4>Large-scale genome-wide association studies (GWAS) of T2D and CVD support a shared genetic ba ...[more]
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