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The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies.


ABSTRACT: We aimed to assess whether vitamin D supplementation improves glucose metabolism in adults with type 2 diabetes.PubMed and Cochrane database were searched up to July 1st 2016 for randomized controlled trials that assessed the relationship between vitamin D supplementation and glucose metabolism (change in hemoglobin A1C (HbA1C) and fasting blood glucose (FBG)) among adults with type 2 diabetes.Twenty nine trials (3324 participants) were included in the systematic review. Among 22 studies included in the meta-analysis, 19 reported HbA1C, 16 reported FBG outcomes and 15 were deemed poor quality. There was a modest reduction in HbA1C (-0.32% [-0.53 to -0.10], I2=91.9%) compared to placebo after vitamin D supplementation but no effect on FBG (-2.33mg/dl [-6.62 to 1.95], I2=59.2%). In studies achieving repletion of vitamin D deficiency (n=7), there were greater mean reductions in HbA1C (-0.45%, [-1.09 to 0.20]) and FBG (-7.64mg/dl [-16.25 to 0.97]) although not significant.We found a modest reduction of HbA1C after vitamin D treatment in adults with type 2 diabetes albeit with substantial heterogeneity between studies and no difference in FBG. Larger studies are needed to further evaluate the glycemic effects of vitamin D treatment especially in patients with vitamin D deficiency.

SUBMITTER: Lee CJ 

PROVIDER: S-EPMC6016376 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies.

Lee Clare J CJ   Iyer Geetha G   Liu Yang Y   Kalyani Rita R RR   Bamba N'Dama N   Ligon Colin B CB   Varma Sanskriti S   Mathioudakis Nestoras N  

Journal of diabetes and its complications 20170421 7


<h4>Aims</h4>We aimed to assess whether vitamin D supplementation improves glucose metabolism in adults with type 2 diabetes.<h4>Methods</h4>PubMed and Cochrane database were searched up to July 1st 2016 for randomized controlled trials that assessed the relationship between vitamin D supplementation and glucose metabolism (change in hemoglobin A1C (HbA1C) and fasting blood glucose (FBG)) among adults with type 2 diabetes.<h4>Results</h4>Twenty nine trials (3324 participants) were included in th  ...[more]

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