Ontology highlight
ABSTRACT:
SUBMITTER: Cheloha RW
PROVIDER: S-EPMC6016400 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cheloha Ross W RW Chen Bingming B Kumar Niyanta N NN Watanabe Tomoyuki T Thorne Robert G RG Li Lingjun L Gardella Thomas J TJ Gellman Samuel H SH
Journal of medicinal chemistry 20171024 21
The parathyroid hormone receptor 1 (PTHR1) is a member of the B-family of GPCRs; these receptors are activated by long polypeptide hormones and constitute targets of drug development efforts. Parathyroid hormone (PTH, 84 residues) and PTH-related protein (PTHrP, 141 residues) are natural agonists of PTHR1, and an N-terminal fragment of PTH, PTH(1-34), is used clinically to treat osteoporosis. Conventional peptides in the 20-40-mer length range are rapidly degraded by proteases, which may limit t ...[more]