Ontology highlight
ABSTRACT:
SUBMITTER: Mueller JW
PROVIDER: S-EPMC6016456 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Mueller Jonathan W JW Idkowiak Jan J Gesteira Tarsis F TF Vallet Cecilia C Hardman Rebecca R van den Boom Johannes J Dhir Vivek V Knauer Shirley K SK Rosta Edina E Arlt Wiebke W
The Journal of biological chemistry 20180509 25
The high-energy sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Sulfotransferase SULT2A1 uses PAPS for sulfation of the androgen precursor dehydroepiandrosterone (DHEA), thereby reducing downstream activation of DHEA to active androgens. Human <i>PAPSS2</i> mutations manifest with undetectable DHEA sulfate, androgen excess, and metabolic disease, suggesting that ubiquitous PAPSS ...[more]