The role of KIBRA in reconstructive episodic memory.

ABSTRACT:

Background

In order to retrieve episodic past events, the missing information needs to be reconstructed using information stored in semantic memory. Failures in these reconstructive processes are expressed as false memories. KIBRA single nucleotide polymorphism (rs17070145) has been linked to episodic memory performance as well as an increased risk of Alzheimer's disease and post-traumatic stress disorder (PTSD).

Methods

Here, the role of KIBRA rs17070145 polymorphism (male and female CC vs. CT/TT carriers) in reconstructive episodic memory in the Deese-Roediger-McDermott (DRM) paradigm was investigated in N = 219 healthy individuals.

Results

Female participants outperformed males in the free recall condition. Furthermore, a trend towards a gender x genotype interacti

SUBMITTER: Zlomuzica A 

PROVIDER: S-EPMC6016870 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature