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Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula.


ABSTRACT: Choushenflavonoids A (1) and B (2), two unusual proline-containing catechin glucosides, were isolated from the roots of Codonopsis pilosula cultivated in a high-altitude location of Yunnan province. Their structures were determined by spectroscopic data and chemical methods. Specifically, the absolute configuration of glucose residue in 1 and 2 was assigned by acid hydrolysis followed by derivatization and gas chromatography (GC) analysis. In addition, biological evaluation of 1 and 2 against Sirtuin 1 (SIRT1) was carried out.

SUBMITTER: Qin FY 

PROVIDER: S-EPMC6017075 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula.

Qin Fu-Ying FY   Cheng Li-Zhi LZ   Yan Yong-Ming YM   Liu Bao-Hua BH   Cheng Yong-Xian YX  

Molecules (Basel, Switzerland) 20180116 1


Choushenflavonoids A (<b>1</b>) and B (<b>2</b>), two unusual proline-containing catechin glucosides, were isolated from the roots of <i>Codonopsis pilosula</i> cultivated in a high-altitude location of Yunnan province. Their structures were determined by spectroscopic data and chemical methods. Specifically, the absolute configuration of glucose residue in <b>1</b> and <b>2</b> was assigned by acid hydrolysis followed by derivatization and gas chromatography (GC) analysis. In addition, biologic  ...[more]

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