Ontology highlight
ABSTRACT:
SUBMITTER: Turan-Zitouni G
PROVIDER: S-EPMC6017090 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Turan-Zitouni Gülhan G Hussein Weiam W Sağlık Begüm Nurpelin BN Tabbi Aouatef A Korkut Büşra B
Molecules (Basel, Switzerland) 20180108 1
A new series of <i>N</i>-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The newly synthesized compounds <b>2a</b>-<b>2n</b> specifically inhibited monoamine oxidases, displaying notably low IC<sub>50</sub> values. Compounds <b>2i</b> and <b>2j</b>, with a CF₃ and OH group on the 4-position of the phenyl ring, respectively, showed considerable MAO ...[more]