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Effects of Dried Blood Spot Storage on Lipidomic Analysis.

ABSTRACT: During the lipidomic analysis of red blood cell membranes, the distribution and percentage ratios of the fatty acids are measured. Since fatty acids are the key constituents of cell membranes, by evaluating their quantities it possible to understand the general health of the cells and to obtain health indicators of the whole organism. However, because the analysis is precise, it is necessary to ensure that the blood does not undergo significant variations between the point of collection and analysis. The composition of the blood may vary dramatically weeks after collection, hence, here an attempt is made to stabilize these complex matrixes using antioxidants deposited on the paper cards on which the blood itself is deposited.

SUBMITTER: Di Marino C

PROVIDER: S-EPMC6017148 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Effects of Dried Blood Spot Storage on Lipidomic Analysis.

Di Marino Cinzia C De Marco Anna A Pisanti Antonio A Romanucci Valeria V

Molecules (Basel, Switzerland) 20180213 2

During the lipidomic analysis of red blood cell membranes, the distribution and percentage ratios of the fatty acids are measured. Since fatty acids are the key constituents of cell membranes, by evaluating their quantities it possible to understand the general health of the cells and to obtain health indicators of the whole organism. However, because the analysis is precise, it is necessary to ensure that the blood does not undergo significant variations between the point of collection and anal ...[more]

PMID: 29438311

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Evaluation of Dried Blood Spot Sampling for Clinical Metabolomics: Effects of Different Papers and Sample Storage Stability.

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903 Protein Saver cards: the best alternative for dried blood spot storage at room temperature for HCV RNA.

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Blood and dried blood spot telomere length measurement by qPCR: assay considerations.

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| S-EPMC3581490 | biostudies-literature

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