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Vinylation of a Secondary Amine Core with Calcium Carbide for Efficient Post-Modification and Access to Polymeric Materials.


ABSTRACT: We developed a simple and efficient strategy to access N-vinyl secondary amines of various naturally occurring materials using readily available solid acetylene reagents (calcium carbide, KF, and KOH). Pyrrole, pyrazole, indoles, carbazoles, and diarylamines were successfully vinylated in good yields. Cross-linked and linear polymers were synthesized from N-vinyl carbazoles through free radical and cationic polymerization. Post-modification of olanzapine (an antipsychotic drug substance) was successfully performed.

SUBMITTER: Rodygin KS 

PROVIDER: S-EPMC6017323 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Vinylation of a Secondary Amine Core with Calcium Carbide for Efficient Post-Modification and Access to Polymeric Materials.

Rodygin Konstantin S KS   Bogachenkov Alexander S AS   Ananikov Valentine P VP  

Molecules (Basel, Switzerland) 20180313 3


We developed a simple and efficient strategy to access <i>N</i>-vinyl secondary amines of various naturally occurring materials using readily available solid acetylene reagents (calcium carbide, KF, and KOH). Pyrrole, pyrazole, indoles, carbazoles, and diarylamines were successfully vinylated in good yields. Cross-linked and linear polymers were synthesized from <i>N</i>-vinyl carbazoles through free radical and cationic polymerization. Post-modification of olanzapine (an antipsychotic drug subs  ...[more]

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