Ontology highlight
ABSTRACT:
SUBMITTER: Tan J
PROVIDER: S-EPMC6017342 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Tan Jie J Zhou Min M Cui Xinhua X Wei Zhuocai Z Wei Wanxing W
Molecules (Basel, Switzerland) 20180312 3
A series of oxime ethers with C₆-C₄ fragment was designed and virtually bioactively screened by docking with a target, then provided by a Friedel-Crafts reaction, esterification (or amidation), and oximation from <i>p</i>-substituted phenyl derivatives (Methylbenzene, Methoxybenzene, Chlorobenzene). Anti-hepatitis B virus (HBV) activities of all synthesized compounds were evaluated with HepG2.2.15 cells in vitro. Results showed that most of compounds exhibited low cytotoxicity on HepG2.2.15 cell ...[more]