Ontology highlight
ABSTRACT:
SUBMITTER: Abonia R
PROVIDER: S-EPMC6017661 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Abonia Rodrigo R Garay Alexander A Castillo Juan C JC Insuasty Braulio B Quiroga Jairo J Nogueras Manuel M Cobo Justo J Butassi Estefanía E Zacchino Susana S
Molecules (Basel, Switzerland) 20180226 3
Two practical and efficient approaches have been implemented as alternative procedures for the synthesis of naftifine and novel diversely substituted analogues <b>16</b> and <b>20</b> in good to excellent yields, mediated by Mannich-type reactions as the key step of the processes. In these approaches, the γ-aminoalcohols <b>15</b> and <b>19</b> were obtained as the key intermediates and their subsequent dehydration catalyzed either by Brønsted acids like H₂SO₄ and HCl or Lewis acid like AlCl₃, r ...[more]