Ontology highlight
ABSTRACT:
SUBMITTER: Karaman B
PROVIDER: S-EPMC6017733 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Karaman Berin B Alhalabi Zayan Z Swyter Sören S Mihigo Shetonde O SO Andrae-Marobela Kerstin K Jung Manfred M Sippl Wolfgang W Ntie-Kang Fidele F
Molecules (Basel, Switzerland) 20180214 2
Sirtuins are nicotinamide adenine dinucleotide (NAD⁺)-dependent class III histone deacetylases, which have been linked to the pathogenesis of numerous diseases, including HIV, metabolic disorders, neurodegeneration and cancer. Docking of the virtual pan-African natural products library (p-ANAPL), followed by in vitro testing, resulted in the identification of two inhibitors of sirtuin 1, 2 and 3 (sirt1-3). Two bichalcones, known as rhuschalcone IV (<b>8</b>) and an analogue of rhuschalcone I (<b ...[more]