Ontology highlight
ABSTRACT:
SUBMITTER: von der Ahe D
PROVIDER: S-EPMC6017835 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
von der Ahe David D Huehnchen Petra P Balkaya Mustafa M Peruzzaro Sarah S Endres Matthias M Boehmerle Wolfgang W
Molecules (Basel, Switzerland) 20180207 2
Suramin is a trypan blue analogon originally developed to treat protozoan infections, which was found to have diverse antitumor effects. One of the most severe side effects in clinical trials was the development of a peripheral sensory-motor polyneuropathy. In this study, we aimed to investigate suramin-induced neuropathy with a focus on calcium (Ca<sup>2+</sup>) homeostasis as a potential pathomechanism. Adult C57Bl/6 mice treated with a single injection of 250 mg/kg bodyweight suramin develope ...[more]