Ontology highlight
ABSTRACT:
SUBMITTER: Marsden MD
PROVIDER: S-EPMC6018613 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Marsden Matthew D MD Wu Xiaomeng X Navab Sara M SM Loy Brian A BA Schrier Adam J AJ DeChristopher Brian A BA Shimizu Akira J AJ Hardman Clayton T CT Ho Stephen S Ramirez Christina M CM Wender Paul A PA Zack Jerome A JA
Virology 20180526
HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination through virus-mediated cytopathic effects, host immune responses, and/or therapeutic strategies targeting cells actively expressing virus. We have recently described several structurally simplified analogs of the PKC modulator LRA bryostatin (te ...[more]