An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles.
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ABSTRACT:
SUBMITTER: Florez LV
PROVIDER: S-EPMC6018673 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles.
Flórez Laura V LV Scherlach Kirstin K Miller Ian J IJ Rodrigues Andre A Kwan Jason C JC Hertweck Christian C Kaltenpoth Martin M
Nature communications 20180626 1
Microbial symbionts are often a source of chemical novelty and can contribute to host defense against antagonists. However, the ecological relevance of chemical mediators remains unclear for most systems. Lagria beetles live in symbiosis with multiple strains of Burkholderia bacteria that protect their offspring against pathogens. Here, we describe the antifungal polyketide lagriamide, and provide evidence supporting that it is produced by an uncultured symbiont, Burkholderia gladioli Lv-StB, wh ...[more]
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