Ontology highlight
ABSTRACT:
SUBMITTER: Arora G
PROVIDER: S-EPMC6019063 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Arora Gunjan G Hart Geoffrey T GT Manzella-Lapeira Javier J Doritchamou Justin Ya JY Narum David L DL Thomas L Michael LM Brzostowski Joseph J Rajagopalan Sumati S Doumbo Ogobara K OK Traore Boubacar B Miller Louis H LH Pierce Susan K SK Duffy Patrick E PE Crompton Peter D PD Desai Sanjay A SA Long Eric O EO
eLife 20180626
Antibodies acquired naturally through repeated exposure to <i>Plasmodium falciparum</i> are essential in the control of blood-stage malaria. Antibody-dependent functions may include neutralization of parasite-host interactions, complement activation, and activation of Fc receptor functions. A role of antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells in protection from malaria has not been established. Here we show that IgG isolated from adults living in a malaria-endem ...[more]