Ontology highlight
ABSTRACT:
SUBMITTER: Inoue R
PROVIDER: S-EPMC6019067 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Inoue Ran R Abdou Kareem K Hayashi-Tanaka Ayumi A Muramatsu Shin-Ichi SI Mino Kaori K Inokuchi Kaoru K Mori Hisashi H
eLife 20180626
Glucocorticoid receptor (GR) is crucial for signaling mediated by stress-induced high levels of glucocorticoids. The lateral nucleus of the amygdala (LA) is a key structure underlying auditory-cued fear conditioning. Here, we demonstrate that genetic disruption of GR in the LA (LAGRKO) resulted in an auditory-cued fear memory deficit for strengthened conditioning. Furthermore, the suppressive effect of a single restraint stress (RS) prior to conditioning on auditory-cued fear memory in floxed GR ...[more]