Ontology highlight
ABSTRACT:
SUBMITTER: Sui L
PROVIDER: S-EPMC6019203 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Sui Lei L Wang Ming M Han Qianqian Q Yu Liming L Zhang Lan L Zheng Leilei L Lian Junxiang J Zhang Jin J Valverde Paloma P Xu Qiaobing Q Tu Qisheng Q Chen Jake J
Biomaterials 20180523
Specific microRNAs (miRs) and the Wnt signaling pathway play critical roles in regulating bone development and homeostasis. Our previous studies revealed the ability of miR-335-5p to promote osteogenic differentiation by downregulating Wnt antagonist Dickkopf-1 (DKK1). The purpose of this study was to use nano-materials to efficiently deliver miR-335-5p into osteogenic cells for tissue engineering applications. We synthesized and screened a library of 12 candidate nano-lipidoids,of which L8 was ...[more]