Ontology highlight
ABSTRACT:
SUBMITTER: Rong E
PROVIDER: S-EPMC6019448 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Rong Enguang E Wang Xiaoxue X Chen Hualan H Yang Chenghuai C Hu Jiaxiang J Liu Wenjie W Wang Zeng Z Chen Xiaoyun X Zheng Haixue H Pu Juan J Sun Honglei H Smith Jacqueline J Burt David W DW Liu Jinhua J Li Ning N Huang Yinhua Y
Frontiers in immunology 20180620
Host cells develop the OAS/RNase L [2'-5'-oligoadenylate synthetase (OAS)/ribonuclease L] system to degrade cellular and viral RNA, and/or the OASL/RIG-I (2'-5'-OAS like/retinoic acid inducible protein I) system to enhance RIG-I-mediated IFN induction, thus providing the first line of defense against viral infection. The 2'-5'-OAS-like (OASL) protein may activate the OAS/RNase L system using its typical OAS-like domain (OLD) or mimic the K63-linked pUb to enhance antiviral activity of the OASL/R ...[more]