Differential expression of cytokines and receptor expression during anoxic growth.
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ABSTRACT:
SUBMITTER: Plotkin BJ
PROVIDER: S-EPMC6019713 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Differential expression of cytokines and receptor expression during anoxic growth.
Plotkin Balbina J BJ Sigar Ira M IM Swartzendruber Julie A JA Kaminski Amber A Davis James J
BMC research notes 20180625 1
<h4>Objective</h4>Cell density in tumor cell three dimensional (3D) cultures affects secretome expression of components. A microenvironment characteristic shared by high-density 3D cell culture and in vivo tumor masses is poor oxygenation, with anoxia being a natural cell state in tumor centers. Until recently, the ability to study anoxia-adapted cell physiology was not possible. Using a newly-developed methodology, anoxic HeLa cell secretome expression was measured.<h4>Results</h4>Anoxic HeLa c ...[more]
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