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ABSTRACT:
SUBMITTER: Koppermann S
PROVIDER: S-EPMC6019934 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Koppermann Stefan S Cui Zheng Z Fischer Patrick D PD Wang Xiachang X Ludwig Jannine J Thorson Jon S JS Van Lanen Steven G SG Ducho Christian C
ChemMedChem 20180323 8
Muraymycins are a subclass of antimicrobially active uridine-derived natural products. Biological data on several muraymycin analogues have been reported, including some inhibitory in vitro activities toward their target protein, the bacterial membrane enzyme MraY. However, a structure-activity relationship (SAR) study on naturally occurring muraymycins based on such in vitro data has been missing so far. In this work, we report a detailed SAR investigation on representatives of the four muraymy ...[more]