Ontology highlight
ABSTRACT:
SUBMITTER: Chuai G
PROVIDER: S-EPMC6020378 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Chuai Guohui G Ma Hanhui H Yan Jifang J Yan Jifang J Chen Ming M Hong Nanfang N Xue Dongyu D Zhou Chi C Zhu Chenyu C Chen Ke K Duan Bin B Gu Feng F Qu Sheng S Huang Deshuang D Wei Jia J Liu Qi Q
Genome biology 20180626 1
A major challenge for effective application of CRISPR systems is to accurately predict the single guide RNA (sgRNA) on-target knockout efficacy and off-target profile, which would facilitate the optimized design of sgRNAs with high sensitivity and specificity. Here we present DeepCRISPR, a comprehensive computational platform to unify sgRNA on-target and off-target site prediction into one framework with deep learning, surpassing available state-of-the-art in silico tools. In addition, DeepCRISP ...[more]