Patient-Specific Quality Assurance Protocol for Volumetric Modulated Arc Therapy using Dose Volume Histogram.

ABSTRACT: A retrospective study was performed to explore the use of dose volume histogram (DVH) metrics in a patient-specific quality assurance protocol for volumetric modulated arc therapy (VMAT). Fourteen head and neck (HN) and ten brain patients treated with VMAT at the Launceston General Hospital were retrospectively analyzed using the new protocol to identify cases where patient dose errors exceed the established action levels that were not originally detected by either point dose and/or gamma index methods. The Sun Nuclear 3DVH software was used to estimate the dose delivered to the patient volume in terms of DVH dose errors. Thus, three different pretreatment verification methods were used to assess if a plan was considered acceptable. In two particular cases, the dose difference determined with point dose was above the established threshold, although it was found that this was due to the placement of the chamber in the phantom. In all cases, 3DVH confirmed that the dose delivered to target volumes (planning target volume - D50%) and to relevant organs at risk was within prescribed dose tolerances. This study has demonstrated the integration of DVH metrics into a VMAT PSQA protocol to provide clinically meaningful results that complement point dose and gamma index measurements. 3DVH should be regarded as an investigative tool that may be useful in diagnosing the cause of failed plans since it allows dose errors to be related to the patient anatomy.

SUBMITTER: Low C 

PROVIDER: S-EPMC6020622 | biostudies-literature | 2018 Apr-Jun

REPOSITORIES: biostudies-literature