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Gender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance in non-diabetic Korean adults.


ABSTRACT: BACKGROUND:The present study was conducted to assess gender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in non-diabetic Korean adults. MATERIALS AND METHODS:A sample including 5,414 adults (2,279 men, 1,529 postmenopausal women, and 1,606 premenopausal women) aged ? 20 years from the fifth Korean National Health and Nutrition Examination Survey (KNHANES V-1, 2010) was analyzed. RESULTS:There were several key findings in the present study. First, in men, HOMA-IR (? = 0.119, 95% confidence interval [CI], 3.304 to 8.003) constituted the independent factor determining ferritin, but this was not the case for HOMA-B (? = -0.042, 95% CI, -0.100 to 0.011). Second, in postmenopausal women, HOMA-IR (? = 0.087, 95% CI, 0.899 to 5.238) was the independent factor determining ferritin, but this was not the case for HOMA-B (? = -0.043, 95% CI, -0.065 to 0.010). Third, in premenopausal women, neither HOMA-IR (? = -0.050, 95% CI, -3.056 to 0.364) nor HOMA-B (? = -0.009, 95% CI, -0.028 to 0.020) constituted the independent factors determining ferritin. CONCLUSIONS:Ferritin was positively associated with insulin resistance in non-diabetic Korean men and postmenopausal women, but not in non-diabetic Korean premenopausal women.

SUBMITTER: Yoon H 

PROVIDER: S-EPMC6021102 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Gender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance in non-diabetic Korean adults.

Yoon Hyun H   Kim Yoon Sik YS   Lee Jun Ho JH   Gi Mi Young MY   Cha Ju Ae JA   Seong Jeong Min JM  

PloS one 20180627 6


<h4>Background</h4>The present study was conducted to assess gender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in non-diabetic Korean adults.<h4>Materials and methods</h4>A sample including 5,414 adults (2,279 men, 1,529 postmenopausal women, and 1,606 premenopausal women) aged ≥ 20 years from the fifth Korean National Health and Nutrition Examination Survey (KNHANES V-1, 2010) was analyzed.  ...[more]

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