Ontology highlight
ABSTRACT:
SUBMITTER: Wang CX
PROVIDER: S-EPMC6021109 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Wang Chen-Xin CX Cui Guan-Shen GS Liu Xiuying X Xu Kai K Wang Meng M Zhang Xin-Xin XX Jiang Li-Yuan LY Li Ang A Yang Ying Y Lai Wei-Yi WY Sun Bao-Fa BF Jiang Gui-Bin GB Wang Hai-Lin HL Tong Wei-Min WM Li Wei W Wang Xiu-Jie XJ Yang Yun-Gui YG Zhou Qi Q
PLoS biology 20180607 6
N6-methyladenosine (m6A) RNA methylation is the most abundant modification on mRNAs and plays important roles in various biological processes. The formation of m6A is catalyzed by a methyltransferase complex including methyltransferase-like 3 (METTL3) as a key factor. However, the in vivo functions of METTL3 and m6A modification in mammalian development remain unclear. Here, we show that specific inactivation of Mettl3 in mouse nervous system causes severe developmental defects in the brain. Met ...[more]