Ontology highlight
ABSTRACT:
SUBMITTER: Cutrin JC
PROVIDER: S-EPMC6021343 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Cutrin Juan Carlos JC Alberti Diego D Bernacchioni Caterina C Ciambellotti Silvia S Turano Paola P Luchinat Claudio C Crich Simonetta Geninatti SG Aime Silvio S
Oncotarget 20180615 46
Cellular uptake of human H-ferritin loaded with 50 or 350 iron ions results in significant cytotoxicity on HeLa cells at submicromolar concentrations. Conversely, Horse Spleen Ferritin, that can be considered a model of L-cages, as it contains only about 10% of H subunits, even when loaded with 1000 iron ions, is toxic only at >1 order of magnitude higher protein concentrations. We propose here that the different cytotoxicity of the two ferritin cages originates from the presence in H-ferritin o ...[more]