Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6021376 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Li Yue Y Stockton Michael E ME Eisinger Brian E BE Zhao Yinghua Y Miller Jessica L JL Bhuiyan Ismat I Gao Yu Y Wu Zhiping Z Peng Junmin J Zhao Xinyu X
Nature communications 20180627 1
Fragile X syndrome (FXS) is the most prevalent inherited intellectual disability, resulting from a loss of fragile X mental retardation protein (FMRP). Patients with FXS suffer lifelong cognitive disabilities, but the function of FMRP in the adult brain and the mechanism underlying age-related cognitive decline in FXS is not fully understood. Here, we report that a loss of FMRP results in increased protein synthesis of histone acetyltransferase EP300 and ubiquitination-mediated degradation of hi ...[more]