Neural correlates of episodic memory in the Memento cohort.

ABSTRACT:

Introduction

The free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory.

Methods

We investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients presenting either with subjective cognitive decline or mild cognitive impairment who underwent cognitive, structural MRI and, for a subset, fluorodeoxyglucose-positron emission tomography evaluations.

Results

Encoding was associated with a network including parietal and temporal cortices; storage was mainly associated with entorhinal and parahippocampal regions, bilaterally; retrieva

SUBMITTER: Epelbaum S 

PROVIDER: S-EPMC6021546 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature