Pharmacokinetic Changes during Pregnancy According to Genetic Variants: a Prospective Study in HIV-Infected Patients Receiving Atazanavir-Ritonavir.
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SUBMITTER: Foca E
PROVIDER: S-EPMC6021630 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Pharmacokinetic Changes during Pregnancy According to Genetic Variants: a Prospective Study in HIV-Infected Patients Receiving Atazanavir-Ritonavir.
Focà Emanuele E Calcagno Andrea A Bonito Andrea A Cusato Jessica J Domenighini Elisabetta E D'Avolio Antonio A Quiros Roldan Eugenia E Trentini Laura L Castelnuovo Filippo F Di Perri Giovanni G Castelli Francesco F Bonora Stefano S
Antimicrobial agents and chemotherapy 20180626 7
Atazanavir-ritonavir concentrations change over time during pregnancy in HIV-positive patients; the impact of genetic variants is unknown. Twenty patients were enrolled in this study; plasma and intracellular concentrations of antiretrovirals were measured, in addition to single-nucleotide polymorphisms in transport-related genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1- and pregnane-X-receptor-encoding genes affected third-trimester atazanavir ex ...[more]
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