Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study.
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ABSTRACT:
SUBMITTER: Chouliaras L
PROVIDER: S-EPMC6021930 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study.
Chouliaras Leonidas L Pishva Ehsan E Haapakoski Rita R Zsoldos Eniko E Mahmood Abda A Filippini Nicola N Burrage Joe J Mill Jonathan J Kivimäki Mika M Lunnon Katie K Ebmeier Klaus P KP
Epigenomics 20180425 5
<h4>Aim</h4>The present study investigated the link between peripheral DNA methylation (DNAm), cognitive impairment and brain aging.<h4>Methods</h4>We tested the association between blood genome-wide DNAm profiles using the Illumina 450K arrays, cognitive dysfunction and brain MRI measures in selected participants of the Whitehall II imaging sub-study.<h4>Results</h4>Eight differentially methylated regions were associated with cognitive impairment. Accelerated aging based on the Hannum epigeneti ...[more]
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