Variants in genes coding for glutathione S-transferases and asthma outcomes in children.
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ABSTRACT:
SUBMITTER: Turner S
PROVIDER: S-EPMC6021964 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Variants in genes coding for glutathione S-transferases and asthma outcomes in children.
Turner Steve S Francis Ben B Wani Nuha N Vijverberg Susanne S Pino-Yanes Maria M Mukhopadhyay Somnath S Tavendale Roger R Palmer Colin C Burchard Esteban G EG Merid Simon Kebede SK Melén Erik E Maitland-van der Zee Anke H AH The Pharmacogenomics In Childhood Asthma Consortium On Behalf Of OBO
Pharmacogenomics 20180522 8
Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and ...[more]
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