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Applications of Synthetic Organic Tetrasulfides as H2S Donors.

ABSTRACT: In an effort to expand the availability of simple polysulfides for H2S donation, we report here the synthesis and H2S release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release H2S in a first-order dependence on reduced glutathione (GSH) and release more H2S than the commonly used trisulfide DATS.

SUBMITTER: Cerda MM

PROVIDER: S-EPMC6022400 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Applications of Synthetic Organic Tetrasulfides as H2S Donors.

Cerda Matthew M MM Hammers Matthew D MD Earp Mary S MS Zakharov Lev N LN Pluth Michael D MD

Organic letters 20170425 9

In an effort to expand the availability of simple polysulfides for H2S donation, we report here the synthesis and H2S release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release H2S in a first-order dependence on reduced glutathione (GSH) and release more H2S than the commonly used trisulfide DATS. ...[more]

PMID: 28440074

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