Ontology highlight
ABSTRACT:
SUBMITTER: Cardamone MD
PROVIDER: S-EPMC6022402 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cardamone Maria Dafne MD Tanasa Bogdan B Cederquist Carly T CT Huang Jiawen J Mahdaviani Kiana K Li Wenbo W Rosenfeld Michael G MG Liesa Marc M Perissi Valentina V
Molecular cell 20180301 5
As most of the mitochondrial proteome is encoded in the nucleus, mitochondrial functions critically depend on nuclear gene expression and bidirectional mito-nuclear communication. However, mitochondria-to-nucleus communication pathways in mammals are incompletely understood. Here, we identify G-Protein Pathway Suppressor 2 (GPS2) as a mediator of mitochondrial retrograde signaling and a transcriptional activator of nuclear-encoded mitochondrial genes. GPS2-regulated translocation from mitochondr ...[more]