Role of inhibitory control in modulating focal seizure spread.
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ABSTRACT:
SUBMITTER: Liou JY
PROVIDER: S-EPMC6022627 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Role of inhibitory control in modulating focal seizure spread.
Liou Jyun-You JY Ma Hongtao H Wenzel Michael M Zhao Mingrui M Baird-Daniel Eliza E Smith Elliot H EH Daniel Andy A Emerson Ronald R Yuste Rafael R Schwartz Theodore H TH Schevon Catherine A CA
Brain : a journal of neurology 20180701 7
Focal seizure propagation is classically thought to be spatially contiguous. However, distribution of seizures through a large-scale epileptic network has been theorized. Here, we used a multielectrode array, wide field calcium imaging, and two-photon calcium imaging to study focal seizure propagation pathways in an acute rodent neocortical 4-aminopyridine model. Although ictal neuronal bursts did not propagate beyond a 2-3-mm region, they were associated with hemisphere-wide field potential flu ...[more]
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