Ontology highlight
ABSTRACT:
SUBMITTER: Fu L
PROVIDER: S-EPMC6022735 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
The journal of physical chemistry letters 20150327 8
Characterization of protein secondary structures at interfaces is still challenging due to the limitations of surface-selective optical techniques. Here, we address the challenge of characterizing parallel β-sheets by combining chiral sum frequency generation (SFG) spectroscopy and computational modeling. We focus on human islet amyloid polypeptide aggregates and a de novo designed short polypeptide at lipid/water and air/glass interfaces. We find that parallel β-sheets adopt distinct orientatio ...[more]