Ontology highlight
ABSTRACT:
SUBMITTER: Rattay S
PROVIDER: S-EPMC6023182 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Rattay Stephanie S Graf Dirk D Kislat Andreas A Homey Bernhard B Herebian Diran D Häussinger Dieter D Hengel Hartmut H Zimmermann Albert A Schupp Anna-Kathrin AK
PloS one 20180628 6
Cholestatic patients exhibiting high bile acid serum levels were reported to be more susceptible to bacterial and viral infections. Animal studies in bile duct ligated (BDL) mice suggest that cholestasis leads to an aggravation of hepatic bacterial infections. We have investigated the impact of cholestasis on mouse cytomegalovirus (MCMV)-induced immune responses and viral replication. While MCMV did not aggravate BDL-induced liver damage, BDL markedly reduced MCMV-triggered chemokine expression ...[more]