Ontology highlight
ABSTRACT:
SUBMITTER: Tian J
PROVIDER: S-EPMC6023608 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Tian Jing J Wu Jiaxi J Chen Xiang X Guo Tong T Chen Zhijian J ZJ Goldstein Joseph L JL Brown Michael S MS
eLife 20180627
In obesity, elevated insulin causes fatty liver by activating the gene encoding SREBP-1c, a transcription factor that enhances fatty acid synthesis. Two transcription factors, LXRα and C/EBPβ, are necessary but not sufficient for insulin induction of hepatic SREBP-1c mRNA. Here, we show that a third transcription factor, BHLHE40, is required. Immunoprecipitation revealed that BHLHE40 binds to C/EBPβ and LXRα in livers of rats that had fasted and then refed. Hepatic BHLHE40 mRNA rises rapidly whe ...[more]