Ontology highlight
ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC6023741 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Zhang Bin B Meng Bo B Viloria Edward E Naveau Adrien A Ganss Bernhard B Jheon Andrew H AH
Cells, tissues, organs 20180316 2
The aim of this study was to evaluate the role of epithelial signal transducer and activator of transcription 3 (STAT3) in mouse incisor amelogenesis. Since Stat3 is expressed in the epithelial component of developing and adult mouse teeth, we generated and analyzed Krt14Cre/+;Stat3fl/fl mutant mice in which Stat3 was inactivated in epithelia including ameloblast progenitors and ameloblasts, the cells responsible for enamel formation. Histological analysis showed little enamel matrix in mutant i ...[more]